Protein Details: Chloride channel protein 2

Protein ID

ICDB_Pro_1613

Protein Name

Chloride channel protein 2

Gene Name

Clcn2; Clc2

Organism

Mus musculus (Mouse)

Length

908 amino acids

AlphaFoldDB

AF-Q9R0A1-F1-model_v4.pdb

Function

Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization; activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase; the rate-limiting enzyme for aldosterone biosynthesis (By similarity).

Sequence

MAAATAAAAAAAAAGEGMEPRALQYEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQAQQWMSRGLNTNILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYEHESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEDLELPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRKAQLSPPSDQESPPSSETSIRFQVNTEDSGFSGAHGQTHKPLKPALKRGPSNSTSLQEGTTGNMESAGIALRSLFCGSPPLEATSELEKSESCDKRKLKRVRISLASDSDPEAEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPRSRHGLPREGTPSDSDDKCQ

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 170; /ligand="chloride" ; BINDING 467; /ligand="chloride" ; BINDING 561; /ligand="chloride"

Disease

Location

Expressed in the adrenal gland and brain

DOI ID

10.1016/s0167-4781(99)00110-4; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001; 10.1038/s41588-018-0048-5; 10.1038/s41588-018-0053-8

RefSeq

NP_034030.2